Knocking-out matrix metalloproteinase-13 exacerbates rotator cuff muscle fatty infiltration
نویسندگان
چکیده
منابع مشابه
Matrix metalloproteinase levels as a marker for rotator cuff tears.
Although many studies report the role of matrix metalloproteinases (MMPs) in rotator cuff tears, a paucity of data exists correlating the clinical severity of the disease with the implicated MMP levels. The purpose of this study was to investigate and compare the levels of expression of MMP-1, -3, -9 and -13 in patients with rotator cuff tears. We hypothesized that patients with clinically wors...
متن کاملSkeletal Muscle Atrophy and Fatty Infiltration after Massive Rotator Cuff Tears in a Novel Rat Model
INTRODUCTION: Rotator cuff tears (RCT) are the most common tendon injury seen in orthopedic patients. Although small tears are amenable to arthroscopic repair, massive RCT repairs can result in re-tears and poor clinical outcomes. Muscle atrophy and fatty infiltration in rotator cuff muscles are major complications of chronic massive RCT and are thought to be among the factors responsible for t...
متن کاملMuscle atrophy and fatty infiltration after an acute rotator cuff repair in a sheep model.
INTRODUCTION rotator cuff tears (RCTs) are the most common tendon injury seen in orthopedic patients. Muscle atrophy and fatty infiltration of the muscle are crucial factors that dictate the outcome following rotator cuff surgery. Though less studied in humans, rotator cuff muscle fibrosis has been seen in animal models as well and may influence outcomes as well. The purpose of this study was t...
متن کاملInvestigating the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after injury.
BACKGROUND rotator cuff muscle atrophy, fibrosis and fatty infiltration are common complications after large and massive rotator cuff tears. Currently, there are no effective treatments for these muscle pathologies after injury. Furthermore, the cellular source for fibrotic and adipose tissues in rotator cuff muscle after injury remains unknown. In this study, we proposed that two groups of mus...
متن کاملMatrix Metalloproteinase and Tissue Inhibitor of Matrix Metalloproteinase Levelsare Specifically Altered in the Torn Rotator Cuff
Introduction: Rotator cuff (RC) disease is the most common cause of shoulder pain in adults (1). The incidence of full-thickness RC tears has been reported to be as high as 40% (2). Several studies have documented the pathological changes associated with RC disease including disruption and thinning of fascicles, foci of granulation tissue, and dystrophic calcification (3). However, despite a la...
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ژورنال
عنوان ژورنال: Muscle Ligaments and Tendons Journal
سال: 2019
ISSN: 2240-4554
DOI: 10.32098/mltj.02.2017.01